High-resolution human core-promoter prediction with CoreBoost_HM
نویسندگان
چکیده
منابع مشابه
High-resolution human core-promoter prediction with CoreBoost_HM.
Correctly locating the gene transcription start site and the core-promoter is important for understanding transcriptional regulation mechanism. Here we have integrated specific genome-wide histone modification and DNA sequence features together to predict RNA polymerase II core-promoters in the human genome. Our new predictor CoreBoost_HM outperforms existing promoter prediction algorithms by p...
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This paper presents an effective core-promoter prediction system on human DNA sequence. The system, named PromSearch, employs a hybrid approach which combines search-by-content method and search-by-signal method. Global statistics of promoter-specific contents are included to represent new significant information underlying the proximal and downstream region around transcription start site (TSS...
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ABSTRACT Background and objectives: Globally, about one third of the population has been infected with Hepatitis B virus (HBV) and more than 400 million people have become chronically infected. Nearly, 20-25% of all carriers develop serious liver diseases such as cirrhosis, chronic hepatitis and hepatocellular carcinoma (HCC). According to t...
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RNA Polymerase II ChIA-PET data has revealed enhancers that are active in a profiled cell type and the genes that the enhancers regulate through chromatin interactions. The most commonly used computational method for analyzing ChIA-PET data, the ChIA-PET Tool, discovers interaction anchors at a spatial resolution that is insufficient to accurately identify individual enhancers. We introduce Ger...
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Despite many recent efforts, in silico identification of promoter regions is still in its infancy. However, the accurate identification and delineation of promoter regions is important for several reasons, such as improving genome annotation and devising experiments to study and understand transcriptional regulation. Current methods to identify the core region of promoters require large amounts...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2008
ISSN: 1088-9051
DOI: 10.1101/gr.081638.108